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Dr Allister J Grant

MB ChB(B'ham) PhD FRCP

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Biography
Dr A.J.Grant is a Consultant Hepatologist (Liver Specialist) at University Hospitals Leicester NHS Trust. He qualified from Birmingham Medical School in 1990 and trained as a Gastroenterologist in the West Midlands then subsequently sub-specialised in Hepatology. He undertook his liver disease training at the Queen Elizabeth Hospital Liver Transplant Unit,  and  completed a successful PhD under the supervision of Prof D.H.Adams. After having completed his Certificate of Specialist Training in Gastroenterology and General (Internal) Medicine he was appointed in November 2004 to University Hospitals Leicester NHS Trust as a Consultant Hepatologist. From 2008-10 he took on the role of Assistant Clinical Director for the Medical Unit at UHL. He is now Head of Service for the Digestive Diseases Centre. Since his initial appointment he has been working with colleagues in University Hospitals Leicester NHS Trust to develop a high quality Liver Service for the people of Leicestershire.
Qualifications:
 
1990 MB, ChB.
1992 MRCP I (UK)
1993 MRCP II (UK) 
2003 PhD (Bham)
 
Prizes/Awards/Scholarships:
 
1986 Nuffield Foundation Student
1989 Nuffield Foundation Bursary (Robert Malcolm Trust Travel Scholarship)
1989 University of Birmingham Medical School,ARC Prize in Rheumatology
2000 MRC Max Perutz 2000 Essay Prize
2003 Peel Medical Research Trust Award
2004 DDF Research Prize 2004 (now CORE) 
2004 CORE/Belmont Trust Award
2008 FRCP
2010 East Midlands Regional Innovation Fund Award

 
Research Fellowships:
 
1998 British Digestive Foundation 1-Year Fellowship.
 
Initial research to show whether adhesion molecules shared between mucosal and hepatic endothelium direct mucosal derived T-cells to the liver leading to an entero-hepatic T-cell re-circulation.

1998 Medical Research Council Clinical Training Fellowship 3 Years
 
Recognition of hepatic endothelium by mucosal lymphocytes promotes the enterohepatic recirculation of T-cells.

2001 University of Birmingham Honorary Research Fellow.
 
Certificates/Courses:
 
2001 ALS Certificated
2002 CCST- Gastroenterology & General Internal Medicine
2010 IRMER/IRR Certificate
2006 Data Protection Registered
2011 Equal Opportunities Course
2011 Child Protection Course

 

Membership of Societies:

  
British Society of Gastroenterology (BSG)- Liver section committee member 2007-10
British Association for the Study of the
Liver (BASL)
British Viral hepatitis Group (BVHG)
European Association for the Study of the Liver (EASL)
West Midlands Gastroenterological Society Committee Member
Member of the “Emerging Leaders in Gastroenterology” Group
Medical Defence Union.
Royal College of Physicians of London.

 
Publications:
 
1.Hypercalcaemia: changing causes over the last 10 years. I Greaves, A Grant, D A Heath, J Michael, D Adu.BMJ 1992; 304:1284

2.Pacemakers: Natural and Artificial. A Grant.Biological Sciences Review. 1995 8(1),2-5.

3.Endoscopy: The Inside Story. A. Grant. Biological Sciences Review.1997.9(4), 6-8

4.The Development of Symptomatic Carpal Tunnel Syndrome after Orthotoptic Liver Transplantation: A Retrospective Analysis.A.Grant, J. Buckels, J. Neuberger. Transplantation 1998:Vol 65(3) 442-444.

5.Guidelines on the use of Liver Biopsy in Clinical Practice. A.J.Grant, J. Neuberger. Gut 1999; 45(Suppl IV) IV1-IV11.

6.Lymphocytes: The Heart of the Immune Response.A.J.Grant. Biological Sciences Review.1999.12(1), 32-35

7.MAdCAM-1 Expressed in Chronic Inflammatory Liver Disease Supports Mucosal Lymphocyte Adhesion to Hepatic Endothelium.Allister J.Grant, Patricia F.Lalor, Stephan Hübscher, Michael Briskin and David H.Adams. Hepatology 2001;33:1065-1072

8.Homing of Mucosal Lymphocytes to the Liver in the Pathogenesis of Hepatic Complications of Inflammatory Bowel Disease. A. Grant, P.F.Lalor, M.Salmi, S.Jalkanen, D.H.Adams. Lancet 2002;359:150-57.

9.Recruitment of Lymphocytes to the Human Liver. P.F.Lalor, P.Shields, A.J.Grant, D.H.Adams. Immunology and Cellular Biology 2002, 80(1):52-64.

10.Hepatic Expression Of Secondary Lymphoid Chemokine (CCL-21) Promotes The Development Of Portal Associated Lymphoid Tissue In Chronic Inflammatory Liver Disease.Allister J. Grant, Sarah Goddard, Jalal Ahmed-Choudray, Gary Reynolds, D.Jackson, Michael Briskin, Lijun Wu, Stefan G Hübscher, & David H. Adams. Am. J. Path 2002 160(4):1445-55

11.Understanding lymphocyte homing and the pathogenesis of inflammatory bowel disease.
D Adams, A Grant, P Lalor. Molecular Insights into Gastroenterology. Gut 2002; 51(Suppl I): I0-I10
 
14. Acute Liver Failure. Grant A.J, Grant M,E. Biological Sciences Review.2005 18(3), 30-34.
 
15. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10, Eksteen B, Miles A, Curbishley SM, Tselepis C, Grant AJ, Walker LS, Adams DH. Journal of Immunology 2006, 171(1):593-603
 

16. Prevalence of Inflammatory bowel disease in patients with airways disease. Raj AA, Birring SS , Grant AJ, de Caestecker J Pavord ID. Respiratory Medicine 2008 May;102(5):780-5.

 

17. IgG4-Positive Sclerosing Cholangitis following Autoimmune

Pancreatitis with deranged CA19.9. Seok L. Ong, Guiseppe Garcea, Florian Puls, Cathy Richards, Kevin Mulcahy, Allister Grant,Ashley R. Dennison, MD, and David P. Berry, MD. International Journal of Surgical Pathology 2008 July;asdoi:10.1177/1066896908319777.

                

18. A Case of Diabetes A Grant, M Grant. Biological Sciences Review 2008, Sept;21(1) 34-37.

 

Papers in Press/Submitted.

Prevalence and Pattern of Airways Disease in Patients with Inflammatory Bowel Disease: 10 years Experience in a Teaching Hospital, Raj AA, Birring SS,Green R, Grant AJ, de Caestecker J, Pavord ID.QJM

Abstracts/Presentations:


1.Large volume paracentesis may be safely performed in subjects with suggested contraindications to the procedure (poster).D.J.Dowling, A.J.Grant, J.Neuberger. Gastroenterology 1998, Vol 114 No.4 Pt2 pG2243

2.MAdCAM-1 expression is increased in primary sclerosing cholangitis and supports lymphocyte adhesion to hepatic endothelium: a mechanism to explain the recruitment of mucosal lymphocytes to the liver in inflammatory bowel disease. A.J.Grant, P.F.Lalor, S.G.Hübscher, M.Briskin, D.H.Adams. BASL (presentation)& AASLD (poster), Hepatology 1999 Suppl,Vol 30, No4, Pt2, 323A

3.MAdCAM-1 is induced in chronic inflammatory liver disease and supports T-cell binding to hepatic endothelium. A.J.Grant. S.G.Hübscher, M.Briskin, D.H.Adams. 8th UK Adhesion Meeting. Harlow (presentation)(1999)

4.Hepatic expression of secondary lymphoid chemokine may promote the recruitment of *4*7+ lymphocytes into the liver. BASL winter 2000 meeting (poster).A.J.Grant, C.Walker, S.Goddard & D.H.Adams.

5.Hepatic expression of secondary lymphoid chemokine may promote the recruitment of *4*7+ lymphocytes into the liver. EASL April 2001 meeting. Prague (poster).A.J.Grant, C.Walker, S.Goddard & D.H.Adams.

6.CCL25(TECK) mediated recruitment of CCR9high gut homing lymphocytes to hepatic endothelium in Primary Sclerosing Cholangitis. Allister J Grant, Bertus Eksteen, Alice Miles, Patricia F Lalor, Stefan G Hübscher, Michael Briskin and David H Adams. 10th UK Adhesion Meeting (poster). Birmingham. 2003
BSG Glasgow (oral presentation) 2004 Gut 2004 53 (Suppl 3) a41
Emerging Leaders in Gastroenterology Conference, Gothenburg (oral presentation) 2004

7.Biliary epithelial expression of VCAM-1 and CXCL12 co-operate in the persistence and survival of lymphocytes in PSC. BASL & AASLD 2004.

8.Biliary epithelial expression of VCAM-1 promotes the survival of lymphocytes in PSC.
Bertus Eksteen, Alice Miles, Mathis Heydtmann, Clare Russell, Allister J Grant, Patricia F Lalor, Chris D Buckley, Michael Salmon, Simon C Afford & David H Adams. BSI 2004

9.CCL25 and CCL28 mediate recruitment of gut homing lymphocytes to the liver in Primary Sclerosing Cholangitis. Bertus Eksteen , Alice Miles , Allister J Grant , Patricia F Lalor , Stefan G Hubscher , Michael Briskin and David H Adams. 12th International Congress of Immunology, Montreal 2004

10.Hepatic endothelial CCL25 mediates recruitment of CCR9+ gut homing lymphocytes to The liver in Primary Sclerosing Cholangitis. FALK Syposia No 146. Innsbruck, Austria, 2005

11.Biliary epithelial injury is associated with CCL28 production and the recruitment of CCR10 effector lymphocytes in human chronic hepatitis. FALK Syposia No 146. Innsbruck, Austria, 2005

12.Regulatory T-cells expressing CCR10 are selectively recruited to epithelial sites in the liver. AASLD (poster) San Francisco / Hepatology Vol 42 (4) Suppl 1, 2005. Bertus Eksteen, Alice Miles, Allister Grant, Stuart Curbishley, Patricia Lalor, Stefan Hubscher, Simon Afford, Mike Briskin, David Adams.

13. Failure to Refer Patients with Positive Hepatitis C Tests:Who is to Blame? Pareek M, Thomas S, Wiselka M, Grant AJ. Federation of Infection Societies, Cardiff 2006.
 
14. Failure to Refer Patients with Positive Hepatitis C Tests: What’s Changed in Leicester? Sahota A, Pareek M, Wiselka M, Grant AJ. Federation of Infection Societies, Nov 2009.